Can you defend the experiment?

Check only what is already true. Aspirational boxes do not count.

There is relevant human evidence—not only animal or pathway data.Prefer trials or strong clinical guidance that match your population and outcome.I can name the specific problem or outcome this is meant to change.“Longevity” is not a measurable target. Sleep, a deficiency, symptoms, or a marker can be.I know the relevant baseline before starting.Without a baseline, improvement and regression are both hard to attribute.Medication, condition, pregnancy, surgery, and interaction risks were reviewed.A qualified clinician or pharmacist should review meaningful interaction risk.This will be the only major supplement change during the test window.Changing a full stack at once destroys attribution.I have a realistic measurement window and adherence plan.The window should match the expected outcome—not internet impatience.I have written a stop rule for side effects, no benefit, or worsening data.A test without a stop rule tends to become permanent by inertia.The recurring cost does not displace higher-value basics or care.Sleep, food quality, training, preventive care, and prescribed treatment usually outrank novelty.

Decision result

Complete the scorecard to expose the missing work before the purchase.

This scorecard is educational. It does not determine whether a supplement is safe, effective, or appropriate for you and does not replace a clinician or pharmacist.

Why the scorecard is deliberately skeptical

Small trials can conflict. For example, one randomized GlyNAC trial in 24 older adults reported improvements across multiple intermediate outcomes, while a separate randomized dose-ranging trial in 114 healthy older adults did not improve its primary glutathione endpoints overall. Likewise, a 2024 meta-analysis of eight NMN trials found no significant improvement in the major glucose and lipid outcomes it assessed.

That does not prove every supplement is useless. It proves that a biological story, a positive small trial, and a longer life are three different claims.

A longevity supplement is an experiment. Design it like one.

Why the scorecard is deliberately skeptical

Primary reading

Why the scorecard is deliberately skeptical

Primary reading

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