Article library · Supplements
Supplements
23 evidence reviews in this category. Every piece states what the human data shows, how large the effect is, and when to talk to a clinician instead.
Omega-3 and Cardiovascular Longevity: What REDUCE-IT and STRENGTH Actually Showed
A deep-dive into the two landmark omega-3 cardiovascular trials, why they produced opposite results, and what the evidence means for EPA and DHA dosing in a longevity protocol.
GlyNAC for Longevity: What the Human Trials Actually Show in 2026
Small human trials report GlyNAC improved biomarkers linked to several aging hallmarks in older adults — and a larger randomized trial missed its primary glutathione endpoint. A full evidence review of what's proven and what isn't.
Does Spermidine Work for Longevity? What the Human Evidence Shows
What the SmartAge trial found, why autophagy mechanisms do not prove longevity benefits, and how to evaluate spermidine food and supplement claims.
Does NMN Actually Work? What 2025 Human Trials Say About NMN and NR for Longevity
NMN and NR supplements reliably raise NAD+ levels — but do they actually improve the things that matter for aging? A 2025 meta-analysis of 10 RCTs found no benefit for muscle mass, strength, or physical function in older adults. Here is a full evidence review across every claimed benefit.
Do Collagen Supplements Actually Work for Skin Aging? What the 2025 Evidence Shows
A 2025 meta-analysis of 23 RCTs found that independent studies show zero benefit from collagen supplements for skin hydration, elasticity, or wrinkles — while industry-funded studies show benefit. Here is what the evidence actually says, what works instead, and how to think about the funding problem in supplement science.
L-Tyrosine and Longevity: What a Major New Study Says Men Should Know
A 272,000-person UK Biobank study using Mendelian randomization found that higher tyrosine levels are linked to nearly a year less of life expectancy in men — but not women. Here is what the evidence actually says about the popular brain supplement, the biological mechanisms, and what to do.
Taurine for Longevity: What the 2025 Evidence Actually Shows
A landmark 2023 Science study made taurine the supplement of the year for longevity. Then three 2025 studies contradicted the core mechanism. Here is an honest evidence breakdown — what changed, what did not, and what you should do.
Methylene Blue for Longevity: The Evidence Behind the Hype, From Mitochondria to Brain Aging
Methylene blue is the oldest synthetic drug in medicine, now trending in longevity circles for its mitochondrial bypass mechanism. Here is what the research actually shows — and the critical safety warnings the biohacker community underplays.
Urolithin A for Longevity: The Science Behind Mitophagy, Immune Aging, and Mitopure
Urolithin A is the mitophagy compound with more human RCT evidence than almost any longevity supplement — yet most people have never heard of it. Here is what the research actually shows, why your gut may not make it from food, and how to supplement effectively.
Senolytics for Longevity: The Science Behind Fisetin, Quercetin, and Clearing Zombie Cells
Senescent 'zombie' cells accumulate as you age and silently accelerate biological aging. Senolytics like fisetin and quercetin are among the most promising longevity compounds of 2026 — here is what the research actually shows, how cyclic dosing works, and what you should do before starting.
Best NAD Boosters Ranked 2026: What to Look for Before You Buy
A practical ranking framework for NAD boosters in 2026, including forms, dosing logic, red flags, and how to tell if a product deserves a place in a longevity stack.
Best Methylene Blue Supplements: How to Evaluate Quality and Fit
A careful guide to methylene blue supplement shopping, with emphasis on purity, dosing caution, contraindications, and what separates a serious product from a risky one.
Best Omega-3 Supplements Ranked 2026: EPA, DHA, Purity, and Value
A buyer-focused omega-3 guide for 2026 covering EPA and DHA balance, oxidation risk, third-party testing, and how to rank fish oil without overpaying.
Best Spermidine Supplements Ranked: What Counts as a Credible Formula
A practical spermidine buying guide covering raw material quality, dose realism, label clarity, and how to separate credible formulas from marketing-led products.
Best Colostrum Supplements Ranked: Quality Signals That Actually Matter
A detailed colostrum supplement guide covering sourcing, immunoglobulin quality, processing, and how to rank products for gut and recovery support.
Glycine for Sleep and Longevity: When It Helps and How to Use It
A practical glycine guide covering sleep support, recovery, dosage strategy, and where this inexpensive amino acid may fit in a longevity routine.
Metformin vs Berberine for Longevity: A Practical Decision Framework
A comparison guide for metformin and berberine in a longevity context, with focus on glucose control, tolerability, monitoring, and when each option may or may not fit.
Best NAD+ Supplements 2026: What Actually Works
A practical, evidence-aware guide to NAD+ supplement options in 2026, including precursors, quality checks, and realistic expectations.
Metformin vs Berberine for Longevity in 2026: Evidence, Tradeoffs, and Decision Framework
A head-to-head comparison of metformin and berberine for glucose control, with the actual trial evidence, real dosing ranges, safety gates, and an honest account of where the longevity data stops.
Longevity Supplements Stack Guide 2026: Evidence Tiers, Dosing Logic, and Safety Workflow
A supplement stack framework built on evidence tiers, studied doses, staged 12-week testing, and explicit stop criteria — including plain statements of where the human evidence runs out for NAD precursors, taurine, senolytics, and clinic-sold longevity therapies.
Best Longevity Supplements Backed by Human Evidence
A practical breakdown of top longevity supplements, what the data says, and how to choose an evidence-first stack.
Metformin vs Berberine for Longevity: Head-to-Head
A practical comparison of metformin and berberine for longevity-focused metabolic goals, including evidence strength, side effects, and decision criteria.
Resveratrol in 2026: Does It Still Matter?
A 2026 update on resveratrol evidence, practical use cases, and how to decide whether it belongs in a longevity stack.