Article library · Science
Science
10 evidence reviews in this category. Every piece states what the human data shows, how large the effect is, and when to talk to a clinician instead.
Rapamycin for Longevity: What the 2026 Evidence Actually Shows
Rapamycin is the most discussed prescription longevity drug — and also the most misunderstood. A deep-dive into mTOR biology, the PEARL trial, real-world off-label use, and the honest risk framework for longevity readers.
GLP-1 Agonists Beyond Weight Loss: What the 2026 Evidence Shows for Heart, Brain, and Longevity
Oral semaglutide just received FDA approval. SELECT showed 20% MACE reduction independent of weight. FLOW showed kidney protection. And signals are emerging for neuroprotection. Here is the complete evidence update on what GLP-1 drugs are proving to do beyond weight loss — and what it means for longevity.
Rapamycin Anti-Aging Guide: What Longevity Readers Should Understand
A measured rapamycin guide covering why it attracts anti-aging interest, what remains uncertain, and how to think about risk, monitoring, and expectations.
Senolytics Guide for Longevity: Dasatinib Plus Quercetin, Fisetin, and Practical Risk Management
What the published dasatinib-plus-quercetin and fisetin trials actually measured, why the one randomized efficacy trial missed its primary endpoint, the specific label risks of dasatinib, and where the evidence for senolytics stops.
Rapamycin for Longevity: What We Know So Far
A balanced review of rapamycin for longevity, covering mechanism, current evidence, uncertainty, and clinician-supervised risk management.
Stem Cell Therapy for Longevity in 2026: Overview, Claims, and Decision Guardrails
What stem cell therapy actually is, where the human evidence stops, the documented harms, and the due-diligence gates to apply before paying a clinic for an aging indication.
Peter Attia's Longevity Framework Explained
A practical breakdown of Peter Attia's core longevity pillars and how to apply the framework without overcomplicating execution.
GLP-1 Agonists and Longevity: Beyond Weight Loss
A practical review of GLP-1 agonists through a longevity lens, including metabolic benefits, body composition concerns, and long-term strategy.
Stem Cell Therapy for Anti-Aging: State of the Art
A state-of-the-art overview of stem cell therapy for anti-aging, including current evidence, real constraints, and safety concerns.
Telomere Length: Can You Actually Reverse Aging?
A science-focused review of telomere length claims, testing limitations, and what telomere data can realistically tell you.