Article library · Science
Science
10 evidence reviews in this category. Every piece states what the human data shows, how large the effect is, and when to talk to a clinician instead.
Rapamycin for Longevity: What the 2026 Evidence Actually Shows
Rapamycin is the most discussed prescription longevity drug — and also the most misunderstood. A deep-dive into mTOR biology, the PEARL trial, real-world off-label use, and the honest risk framework for longevity readers.
GLP-1 Agonists Beyond Weight Loss: What the 2026 Evidence Shows for Heart, Brain, and Longevity
Oral semaglutide just received FDA approval. SELECT showed 20% MACE reduction independent of weight. FLOW showed kidney protection. And signals are emerging for neuroprotection. Here is the complete evidence update on what GLP-1 drugs are proving to do beyond weight loss — and what it means for longevity.
Rapamycin Anti-Aging Guide: What Longevity Readers Should Understand
A measured rapamycin guide covering why it attracts anti-aging interest, what remains uncertain, and how to think about risk, monitoring, and expectations.
Senolytics Guide for Longevity: Dasatinib Plus Quercetin, Fisetin, and Practical Risk Management
A detailed senolytics primer for longevity readers covering mechanism hypotheses, protocol uncertainty, safety constraints, and decision criteria before experimentation.
Rapamycin for Longevity: What We Know So Far
A balanced review of rapamycin for longevity, covering mechanism, current evidence, uncertainty, and clinician-supervised risk management.
Stem Cell Therapy for Longevity in 2026: Overview, Claims, and Decision Guardrails
A balanced stem cell therapy overview for longevity readers, covering realistic indications, evidence gaps, clinic due diligence, and risk-aware decision-making.
Peter Attia's Longevity Framework Explained
A practical breakdown of Peter Attia's core longevity pillars and how to apply the framework without overcomplicating execution.
GLP-1 Agonists and Longevity: Beyond Weight Loss
A practical review of GLP-1 agonists through a longevity lens, including metabolic benefits, body composition concerns, and long-term strategy.
Stem Cell Therapy for Anti-Aging: State of the Art
A state-of-the-art overview of stem cell therapy for anti-aging, including current evidence, real constraints, and safety concerns.
Telomere Length: Can You Actually Reverse Aging?
A science-focused review of telomere length claims, testing limitations, and what telomere data can realistically tell you.